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BBM-928 A

Product Name
BBM-928 A
CAS No.
75580-37-9
Chemical Name
BBM-928 A
Synonyms
BBM-928 A;Aids082344;Aids-082344;Luzopeptin a;Luzopeptin A (9CI);Antibiotic bbm-928a;85255-31-8 (Deleted);Diacetyl-luzopeptin c;Antibiotic bbm 928C, 2,7-diacetate;2-Quinolinecarboxamide, N,N'-[4,23-bis(acetyloxy)-4,4A,5,6,7,8,9,10,11,12,13,14,17,18,23,23A,24,25,26,27,28,29,30,31,32,33,36,37-octacosahydro-13,32-bis(1-hydroxy-1-methylethyl)-9,12,28,31-tetramethyl-5,8,11,14,18,24,27,30,33,37-decaoxo-3H,16H,22H,35H-dipyridazino[6,1-L:6',1'-B1][1,17,4,7,10,13,20,23,26,29]dioxaoctaazacyclodotriacontine-17,36-diyl]bis[3-hydroxy-6-methoxy-, [4S-(4R*,4ar*,13R*,17S*,23R*,23ar*,32R*,36S*)]-
CBNumber
CB01356423
Molecular Formula
C64H78N14O24
Formula Weight
1427.38
MOL File
75580-37-9.mol
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BBM-928 A Property

Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO;Soluble in dimethyl formamide
form 
solid
pka
6.75±0.40(Predicted)
color 
tan
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18444
Product name
Luzopeptin A
Purity
≥99%
Packaging
1mg
Price
$335
Updated
2024/03/01
Cayman Chemical
Product number
18444
Product name
Luzopeptin A
Purity
≥99%
Packaging
5mg
Price
$966
Updated
2022/04/27
TRC
Product number
L482003
Product name
LuzopeptinA
Packaging
1mg
Price
$225
Updated
2021/12/16
Usbiological
Product number
L7520
Product name
Luzopeptin A
Packaging
1mg
Price
$523
Updated
2021/12/16
ApexBio Technology
Product number
C4392
Product name
LuzopeptinA
Packaging
1mg
Price
$381
Updated
2021/12/16
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BBM-928 A Chemical Properties,Usage,Production

Uses

Luzopeptin A is a cyclic depsipeptide antibiotic first isolated from an actinomycete strain. It displays antitumor activity, as it is highly active in mice against a variety of experimental tumors. Luzopeptin A acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules. It also inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases.[Cayman Chemical]

Uses

Luzopeptin A is an inhibitor of HIV-1 and HIV-2 reverse transcriptase.

Uses

Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents that act by forming a stable DNA complex by bis-intercalation. Luzopeptin A is alsoa potent inhibitor of HIV-1 reverse transcriptase.

Biological Activity

luzopeptin a is a cyclic depsipeptide antibiotic.a depsipeptide is a peptide in which one or more of its amide groups are replaced by the corresponding ester, or more generally, is a molecule that has both peptide and ester linkages in proximity in the same amino acid-containing small molecule or chain.

in vitro

previous study found that luzopeptin a treatment could produce additional dna bands which were the products of type ii biintercalation. the types of restriction fragments involved were identified. maximal type ii biintercalation occurred at a luzopeptin a/dna range of 0.14 to 0.18, at which more than 50% of the total dna molecules were involved. type ii products were gradually converted to type i products upon prolonged incubation at 37 degrees, maybe due to the tendency for intermolecular bonds to disrupt. echinomycin treatment failed to produce type ii products, probably because of a dna-binding affinity weaker than that of luzopeptin a [1].

in vivo

animal study showed that when administered as a suspension in 0.9% nacl solution, luzopeptin a demonstrated good activity against i.p. b16 melanoma and i.p. p388 leukemia and weak activity versus i.v. p388, i.p. l1210 leukemia, lewis lung, and madison 109 lung carcinomas. in terms of tumor cell kill, luzopeptin a induced net reductions in the body burdens of l1210 and p388 leukemias following single-drug injections but failed to yield net reductions following multiple-injection therapies [2].

References

[1] huang, c. h.,mirabelli, c.k.,mong, s., et al. intermolecular cross-linking of dna through bifunctional intercalation of an antitumor antibiotic, luzopeptin a (bbm-928a). cancer research 43, 2718-2724 (1983).
[2] rose wc, schurig je, huftalen jb, bradner wt. experimental antitumor activity and toxicity of a new chemotherapeutic agent, bbm 928a. cancer res. 1983 apr;43(4):1504-10.

BBM-928 A Preparation Products And Raw materials

Raw materials

Preparation Products

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BBM-928 A Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58

75580-37-9, BBM-928 ARelated Search:


  • BBM-928 A
  • 2-Quinolinecarboxamide, N,N'-[4,23-bis(acetyloxy)-4,4A,5,6,7,8,9,10,11,12,13,14,17,18,23,23A,24,25,26,27,28,29,30,31,32,33,36,37-octacosahydro-13,32-bis(1-hydroxy-1-methylethyl)-9,12,28,31-tetramethyl-5,8,11,14,18,24,27,30,33,37-decaoxo-3H,16H,22H,35H-dipyridazino[6,1-L:6',1'-B1][1,17,4,7,10,13,20,23,26,29]dioxaoctaazacyclodotriacontine-17,36-diyl]bis[3-hydroxy-6-methoxy-, [4S-(4R*,4ar*,13R*,17S*,23R*,23ar*,32R*,36S*)]-
  • 85255-31-8 (Deleted)
  • Aids082344
  • Aids-082344
  • Antibiotic bbm 928C, 2,7-diacetate
  • Antibiotic bbm-928a
  • Diacetyl-luzopeptin c
  • Luzopeptin a
  • Luzopeptin A (9CI)
  • 75580-37-9
  • C64H78N14O24